Clonal spread of mef-positive macrolide-resistant Streptococcus pneumoniae isolates causing invasive disease in adults in Germany.

Clonal spread of mef positive macrolide-resistant Streptococcus pneumoniae in invasive disease in adults in Germany

mef(A), mef(E) and a new mef allele in macrolide-resistant Streptococcus spp. isolates from Norway.

OBJECTIVES To type mef genes in a nationwide collection of clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes as well as pharyngeal carrier strains of viridans streptococci in Norway. METHODS Erythromycin-resistant mef-positive multilocus sequence-typed (MLST) clinical isolates of S. pneumoniae (n = 36) and S. pyogenes (n = 12) from the National Surveillance Program for ...

Phenotypes and genotypes of macrolide-resistant streptococcus pneumoniae.

BACKGROUND Macrolide resistance in Streptococcus pneumoniae (S. pneumoniae) is a worldwide problem. AIMS The aim of this work was to analyze the phenotypes, genotypes, and clonal relatedness among macrolide-resistant S. pneumoniae strains isolated from various clinical specimens in our hospital. STUDY DESIGN Cross-sectional study. METHODS 80 non-duplicate S. pneumoniae strains were analyz...

Macrolide resistance determinants in erythromycin-resistant Streptococcus pneumoniae in Turkey.

To determine the major molecular mechanisms of macrolide resistance among Streptococcus pneumoniae isolates in Turkey, we examined a total of 151 isolates collected from different regions of Turkey. Overall, 40 (26.4%) isolates were resistant to erythromycin. The most common mechanism (38/40) was target site modification due to erm (B) genes. Only two isolates harbored the mef (A)/(E) efflux ge...

Emergence and Spread of Streptococcus pneumoniae with erm(B) and mef(A) Resistance

Streptococcus pneumoniae isolates (N = 31,001) were collected from patients with community-acquired respiratory tract infections during the PROTEKT US surveillance study (2000-2003). While the macrolide (erythromycin) resistance rate remained stable at approximately 29%, the prevalence of resistant isolates containing both erm(B) and mef(A) increased from 9.7% in year 1 to 16.4% in year 3, with...